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Wednesday, August 12, 2020 | History

2 edition of Some sulphur-containing fused pyrimidine derivatives. found in the catalog.

Some sulphur-containing fused pyrimidine derivatives.

Ian W. Southon

Some sulphur-containing fused pyrimidine derivatives.

by Ian W. Southon

  • 221 Want to read
  • 16 Currently reading

Published by University of Salford in Salford .
Written in English


Edition Notes

PhD thesis, Chemistry & Applied Chemistry.

SeriesDX178912
ID Numbers
Open LibraryOL20407189M

The term pteridine has long been applied to the ring systems composed of fused pyrimidine and pyrazine ring and some of pteridine derivatives have been patented in United States Compounds having 5,6,7,8-tetrahydropteridine nucleus have been found to posses diuretic and antihypertensive activity and they are useful as intermediates for. Three series of new pyrimidine derivatives were synthesized and their antifungal activities were evaluated in vitro against fourteen phytopathogenic fungi. The results indicated that most of the synthesized compounds possessed fungicidal activities and some of them are more potent than the control fungicides. Preliminary SAR was also discussed.

In this work, we report the synthesis and characterization of new compounds derived from thieno[d] formation of isolated and fused thieno[d]pyrimidine derivatives was achieved via reacting 5-amino-(2-methyl)thieno[3,4-d]pyrimidin-4(3H)-one (3) with some selected starting compound (2) was prepared in a quantitative yield using a modified procedure by conversion . The synthesis, preparation, chemical reactivities and biological activity of simple heterocyclic and heteropolycyclic nitrogen systems as small units as functional pyrazoles, pyridine and pyrimidine, and the related fused systems are reviewed. Among the various possible routes to the formation, isomeric structures have been cited because of patented reaching advanced phases of clinical trials.

Pyridine-2(1H)-thione 1 reacted with phenyl isothiocyanate to give pyrido[2,3-d]pyrimidine derivative nd 3 reacted with halogen containing compounds 4a–d and methyl iodide in dimethylformamide/potassium hydroxide solution at room temperature to give 2,7-bisalkylthiopyrido[2,3-b]pyrimidine derivatives 5a–d and 9, nds 5a–d could be cyclized into .   1. Introduction. Pyrazole derivatives are important intermediates in organic synthesis and possess a range of interesting biological and antimicrobial properties [1,2,3,4,5,6,7,8].Their fused pyrimidine derivatives are used as dyes [9,10,11,12,13,14].In the current study, we prepared new azopyrazolopyrimidine dyes, starting with 3-amino(4-hydroxyphenyl)azo-1Hpyrazolineones .


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Some sulphur-containing fused pyrimidine derivatives by Ian W. Southon Download PDF EPUB FB2

Biological activities of Fused Pyrimidine Derivatives – A Review: Pyrimidine as Antimicrobial and Anti TB Agent [Panneer Selvam, Theivendren, Raisa Valadares, Joela, Asaraf Ali, Mohamed] on *FREE* shipping on qualifying offers. Biological activities of Fused Pyrimidine Derivatives – A Review: Pyrimidine as Antimicrobial and Anti TB AgentAuthor: Theivendren Panneer Selvam, Joela Raisa Valadares, Mohamed Asaraf Ali.

Title:Pyrimidine-fused Derivatives: Synthetic Strategies and Medicinal Attributes VOLUME: 16 ISSUE: 28 Author(s):Gaurav Joshi, Himanshu Nayyar, Jimi Marin Alex, Gajendra S. Vishwakarma, Sunil Mittal and Raj Kumar Affiliation:Laboratory for Drug Design and Synthesis, Centre for Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences, Central University of Punjab.

A series of triazole-pyrimidine derivatives were designed and synthesized as LSD1 inhibitors based on the hit compound 8a from our in-house compound library.

Among them, compound 15u was identified as the most potent, selective and reversible LSD1 inhibitor, and also demonstrated excellent cellular inhibitory activities against AML cell lines. Download: Download high-res image Cited by: Combination of sulphamethoxazole with pyrimethamine is a novel antimalarial drug [9].

Pyrimidinone-amides derivatives of dihydropyrimidines (Hsp70 modulators), could inhibit the replication Some sulphur-containing fused pyrimidine derivatives. book the pathogenic P. falciparum stages in human red blood cells (Figures 10 & 11).

Synthesis, Characterization and Antitumor Activity of Some Novel Pyrimidine Sulfonamide Derivatives Samir M Awad1, Mohamed F El-Shehry2*, Rasha S Gouhar3 and Salwa M El-Hallouty4 1Pharmaceutical Organic Chemistry Department, Helwan University, Egypt 2Pesticide Chemistry Department, National Research Centre, Dokki, Giza, Egypt.

Pyrimidines De novo Pyrimidine Synthesis in Apicomplexa Unique Architecture, Organization and Regulation of CPSII in Apicomplexa CPSII Activity Required for de Novo Pyrimidine Synthesis is a Validated Drug Target A series of novel 1,3,4-thiadiazole derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety were synthesized by the method of splicing active substructures.

Among these derivatives, compounds. Fusion of pyrimidine moiety with different heterocycle scaffolds gives rise to a new class of hybrid heterocycles possessing improved activity. Heterocycles containing sulphur and nitrogen atoms in the core structure, shows number of pharmacologically and biologically active compounds.

So, various fused pyrimidines like purines, pteridines, quinazolines, pyridopyrimidines, triazolopyrimidines. Biological activities of Fused Pyrimidine Derivatives – A Review.

Book January Some new compounds derived from imidazo[1,2-a]pyridine, The newly synthesized compounds were. The synthesis of fused pyrimidines from the Schiff bases of aromatic ortho-nitrocarbaldehydes is reported. The Schiff bases after selective reduction of the nitro group on 10% Pd/C, followed by condensation of the amines formed with orthoesters, are transformed to the corresponding imidates.

Heating of the latter in a sealed tube with an excess of ammonia (or with ammonia in ethanol) gives. many of these derivatives may block proliferation of various cancer cell lines (27).

Based on the above observation and in continuation of our search work (), herein we reported the synthesis of some new pyridine, pyrimidine, fused pyrimidine and cyclohexenone derivatives and evaluating their antibacterial activity.

II- ESULTS AND DISCUSION. This book entitled “Pyrimidine Chemistry: Synthesis, Structure and Bioactivity of some Uracil Derivatives” comprises of seven Chapters. Each chapter is divided into sections namely Introduction, Materials and Methods, Results and Discussion (including Bioactivity test), Conclusion, Experimental Section and References respectively (excluding Chapters 1 & 7).

FUSED PYRIMIDINES Scheme 2. Synthesis of compounds 5–10; Ar = C6H,4-(O–CH2–O) for 6, 7, 9 and Treatment of 11a with bi-functional nucleophilic substrates, i.e., sodium azide and thiourea, afforded the tetrazolo pyrimid and pyrimido pyri- mid respectively (Scheme 3).

Reaction of 2-thioxopyrimidines and b with benzylamine in 1a n-butanol. Fused pyrimidine cores are privileged kinase scaffolds, yet few examples of the 2-amino-pyrido[3,4-d]pyrimidine chemotype have been disclosed in the context of kinase inhibitor rmore, no general synthetic route has been reported to access 2-amino-pyrido[3,4-d]pyrimidine we report a versatile and efficient chemical approach to this class of molecules.

Fused pyrimidine systems: XVII. Arylsulfenylation of 5-allylpyrimidine-4(3H)-one derivatives. Synthesis of arylsulfanyl-substituted 5,6-dihydrofuro[2,3-d]- and 6,7-dihydro-5H-pyrano[2,3-d]pyrimidines. Unexpected deviation from diene behaviour of uracil amidine: towards synthesis of some pyrido[2,3-d]pyrimidine derivatives.

Molecular Diversity15 (3), DOI: /sy. Ragini Gupta, Anshu Jain, Rahul Joshi, Meenakshi Jain. To synthesize and characterize novel pyrimidine derivatives and screen them for anti-inflammatory activity.

A series of four 6, 7-dihydroaceto substituted pentaleno [2, 1-d] pyrimidinone derivatives (PM1-PM4) were synthesized from 2-amino-3, 4, 5, 6-tetra hydro pentalenecarboxamide.

This part of Volume 24 in the series completes the review of fused pyrimidines in which the second ring is six-membered and contains one or more of the elements of nitrogen, oxygen or sulphur.

It is a critical survey of synthetic methods and reactions of each class of compound. Background: Substituted pyrimidine derivatives (non-nucleoside) are found to be associated with various biological activities.

The various substituted pyrimidines are also having significant in vitro activity against different DNA and RNA viruses. The present study focuses on the anti-PV activity of new pyrimidines and their condensed derivatives.

Fused Pyrimidines: Part Four Miscellaneous Fused Pyrimidines (The Chemistry of Heterocyclic Compounds, Vol Part 4) by Delia, Thomas J.

and a great selection of related books, art and collectibles available now at. An efficient synthesis of functionalized fused pyrimidine derivatives from the respective ortho-(isocyanomethyl)nitroarenes is described: hydrolysis of the isocyano group in the title isocyanides followed by catalytic reduction of the nitro group and subsequent cyclocondensation of the diamine formed with orthoeste.Synthesis and characterization of fused pyrimidine derivatives The synthesis of hitherto unreported title compounds were carried out, as outlined in Schemes (p.

44, 49 and 52). The molecular weight, % yield, time for microwave irradiation (MWI) in min, melting point. Treatment of 4 with ethyl acetoacetate, acetic anhydride, formic acid, urea and thiourea gave the corresponding pyrido [2,3-d] pyrimidine derivatives 7–10a,b.

A new series of 6-substitutedmethylphenylpyridine carbonitriles 11–13 has been synthesized via reaction of 4 with phenyl isothiocyanate, benzenesulphonyl chloride and acetic.